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Department of Chemistry and Physics

FSU HomeChemistryFaculty and StaffShubo Han

Shubo Han, Ph.D.

Dr. Han

B.E., Hebei University of Science and Technology
Ph.D. & M.S., University of Science and Technology of China

Professor of Chemistry

Coordinator of FSU "3+2" Engineering Programs

Office: LSA 334
Phone: (910)  672-1303

Research Site:


  • Instrumental Analysis Lecture (CHEM 311) and Lab (CHEM 311L)

  • Analytical Chemistry Lecture (CHEM 211) and Lab (CHEM 211L)

  • Nanoscience and Nanotechnology (CHEM 423)

  • Chemical Research and Ethics (CHEM 490)

  • General Chemistry Lectures and Labs, CHEM 141, CHEM 142, CHEM 161, CHEM 162

Research Interests

  • Atomic Force Microscopy of Surface Interaction of Biological Species (DNA, proteins and drugs)

  • Fabrication and Characterization of Nanomaterials (Nanoarray, Nanotube, Nanoparticles) and Bio-functionalized Nanomaterials

  • Electrochemical and Optical Biosensor Development

Selected Publications

30. Zhu, M.; Patel, S. H.; Han, S.DJ-1, A Parkinson's disease related protein, aggregates under denaturing conditions and co-aggregates with α-synuclein through hydrophobic interaction. Biochimica et Biophysica Acta (BBA) - General Subjects, In Press.

29. Kharabsheh, H. A.; Han, S.;  Allen, S; Chao, S.L. Metabolism of chlorpyrifos by Pseudomonas aeruginosa increases toxicity in adult zebrafish (Danio rerio).  International Biodeterioration & Biodegradation, 2017, 121, 114-121.

28.   Han, S.;  Umera, K.;  Han, X.; Graham. J.M. Surface Electrochemical Oxidation and Polymerization Mechanism of Epicatechin, Electrochemica Acta, 2013, 90, 27-34.

27. Zhu,M;   Han,S.;  Fink, A.L.. Oxidized Quercetin Inhibits α-Synuclein Fibrillization, Biochimica et Biophysica Acta (BBA)-General Subjects. 2013, 1830, 2872-2881.

26.  Jiang,D.;  Rauda, I.;  Han, S.;  Chen, S.;  Zhou, F. Aggregation Pathways of the Amyloid β(1-42) Peptide Depend on Its Colloidal Stability and Ordered β-Sheet Stacking, Langmuir, 2012, 28, 12711-12721.

25.    Bhattacharya, P.;   Czejdo,B.; Han,S.;  Siddique, M. Behavior Based Approach for Robot Navigation and Chemical Anomaly Tracking. in S. Jeschke, H. Liu, and Schilberg (Eds.): ICIRA 2011, Part II, LNAI 7102, pp. 317-327, 2011. Springer-Verlag Berlin Heidelberg 2011.

24.    Hong, D.; Han, S.; Fink, A. L., N. Uversky, N. V. Characterization of the Non-Fibrillar α-Synuclein Oligomers(2011), Protein and Peptide Letters, 18( 3), pp. 230-240.

23. Qin, Z.; Hu, D.; Han, S.; Hong, D.; Fink, A.L. Role of different regions of a -synuclein in the assembly of fibrils. Biochemistry (2007), 46(46), 13322-133

22. Qin, Z.; Hu, D.; Han, S.; Reaney, S. H.; Di Monte, D. A.; Fink, A.L. Effect of 4-hydroxy-2-nonenal modification on a -synuclein aggregation. Journal of Biological Chemistry (2007), 282(8), 5862-5870.

21. Martinez, Z.; Zhu, M; Han, S.; Fink, A.L. GM1 specifically interacts with a-synuclein and inhibits fibrillation. Biochemistry (2007), 46(7), 1868-1877.

20. Wang, J.; Zhu X.; Han, S. Electrochemistry of bilayer lipid membranes. Recent Res. Devel. Biophys., 5(2006): 319-332.

19. Wang, Y., Han, S., Briseno, A.L., Sanedrin, R.J.G., and Zhou, F., A modified nanosphere lithography for the fabrication of aminosilane/polystyrene nanoring arrays and the subsequent attachment of gold or DNA-capped gold nanoparticles. Journal of Materials Chemistry, 2004, 14. 3488-3494.

18. Zhu, M., Han, S., Zhou, F., Carter, S.A., and Fink, A.L., Annular oligomeric Amyloid Intermediates Observed by in Situ Atomic Force Microscopy. Journal of Biological Chemistry, 2004. 279(23): 244529.

17. Zhu, M., Rajamani, S., Kaylor, J., Han, S., Zhou, F., and Fink, A.L., The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils. Journal of Biological Chemistry, 2004. 279(26): 26846-57.

16. Briseno, A.L., Han, S., Rauda, I.E., Zhou, F., Toh, C.-S., Nemanick, E.J., and Lewis, N.S., Electrochemical Polymerization of Aniline Monomers Infiltrated into Well-Ordered Truncated Eggshell Structures of Polyelectrolyte Multilayers. Langmuir, 2004. 20(1): 219 -226.

15. Han, S., Sun, X.Z., Wang, J., Li, X., Zhou, F.M., and Momand, J., AFM studies of interactions of proteins with surface-confined ds DNA. Biophysical Journal, 2003. 84(2): 471A-471A.

14. Han, S., Ralin, D., Wang, J., Li, X., and Zhou, F., Attachment of Monoclonal Antibody Molecules to Surface-Confined DNA Duplexes Imaged by Atomic Force Microscopy. Langmuir, 2003. 19(21): 8943-89509.

13. Chickneyan, Z.S., Briseno, A.L., Shi, X., Han, S., Huang, J., and Zhou, F., Polyelectrolyte-Mediated Assembly of Copper Phthalocyanine Tetrasulfonate Multilayers and the Subsequent Production of Nanoparticulate Copper Oxide Thin Films. Journal of Nanoscience and Nanotechnology, 2004. 4: 628-634.

12. Sun, X.Z., Vinci, C., Makmura, L., Han, S., Tran, D., Nguyen, J., Hamann, M., Grazziani, S., Sheppard, S., Gutova, M., Zhou, F., Thomas, J., and Momand, J., Formation of Disulfide Bond in p53 Correlates with Inhibition of DNA Binding and Tetramerization. Antioxidants & Redox Signaling, 2003. 5(5): 655-665.

11. Han, S., Briseno, A.L., Shi, X., Mah, D.A., and Zhou, F., Polyelectrolyte-coated nanosphere lithographic patterning of surfaces: Fabrication and characterization of electropolymerized thin polyaniline honeycomb films. Journal of Physical Chemistry B, 2002. 106(25): 6465-6472.

10. Han, S., Shi, X., and Zhou, F., Polyelectrolyte Hollow Sphere Lithographic Patterning of Surfaces: Construction of 2-Dimensional Well-Ordered Metal Arrays. Nano Letters, 2002. 2(2): 97-100.

9. Shi, X., Han, S., Sanedrin, R.J., Galvez, C., Ho, D.G., Hernandez, B., Zhou, F., and Selke, M., Formation of Cobalt Oxide Nanotubes: Effect of Intermolecular Hydrogen Bonding between Co(III) Complex Precursors Incorporated onto Colloidal Templates. Nano Letters, 2002. 2(4): 289-293.

8. Shi, X., Han, S., Sanedrin, R.J., Zhou, F., and Selke, M., Synthesis of Cobalt Oxide Nanotubes from Colloidal Particles Modified with a Co(III)-Cysteinato Precursor. Chemistry of Materials, 2002. 14(4): 1897-1902.

7. Huang, E., Satjapipat, M., Han, S., and Zhou, F., Surface Structure and Coverage of an Oligonucleotide Probe Tethered onto a Gold Substrate and Its Hybridization Efficiency for a Polynucleotide Target. Langmuir, 2001. 17(4): 1215-1224.

6. Han, S., Lin, J., Satjapipat, M., Baca, A.J., and Zhou, F., A three-dimensional heterogeneous DNA sensing surface formed by attaching oligodeoxynucleotide-capped gold nanoparticles onto a gold-coated quartz crystal. Chemical Communications (Cambridge, United Kingdom), 2001(7): 609-610.

5. Han, S., Lin, J., Zhou, F., and Vellanoweth, R.L., Oligonucleotide-Capped Gold Nanoparticles for Improved Atomic Force Microscopic Imaging and Enhanced Selectivity in Polynucleotide Detection. Biochemical and Biophysical Research Communications, 2000. 279: 265-269.

4. Han, S., Zhu, M., Yuan, Z., and Li, X., A methylene blue-mediated enzyme electrode for the determination of trace mercury(II), mercury(I), methylmercury, and mercury-glutathione complex. Biosensors & Bioelectronics, 2001. 16(1-2): 9-16.

3. Zhu, M., Han, S., and Yuan, Z., beta-cyclodextrin polymer as the immobilization matrix for peroxidase and mediator in the fabrication of a sensor for hydrogen peroxide. Journal of Electroanalytical Chemistry, 2000. 480(1-2): 255-261.

2. Han, S., Li, X., Guo, G., Sun, Y., and Yuan, Z., Voltammetric measurement of microorganism populations. Analytica Chimica Acta, 2000. 405(1-2): 115-121.

1. Yuan, Z., Zhu, M., and Han, S., Supramolecular inclusion complex formation and application of b-cyclodextrin with heteroanthracene ring cationic dyes. Analytica Chimica Acta, 1999. 389(1-3): 291-298.


    1. Rassman, W., Ralin, D., Zhou, F., and Han, S., Method and apparatus for recognizing molecular compounds, in U.S. Pat. Appl. Publ. 2003, (USA). Us. p. 17 pp.

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