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Department of Chemistry and Physics

FSU HomeChemistryOur PeopleShubo Han

Shubo Han, Ph.D.

Dr. Han

B.E., Hebei University of Science and Technology
Ph.D. & M.S., University of Science and Technology of China

Professor of Chemistry

Coordinator of FSU "3+2" Engineering Programs

Office: LSA 334
Phone: (910)  672-1303

Research Site:


  • Instrumental Analysis Lecture (CHEM 311) and Lab (CHEM 311L)

  • Analytical Chemistry Lecture (CHEM 211) and Lab (CHEM 211L)

  • Nanoscience and Nanotechnology (CHEM 423)

  • Chemical Research and Ethics (CHEM 490)

  • General Chemistry Lectures and Labs, CHEM 141, CHEM 142, CHEM 161, CHEM 162

Research Interests

  • Atomic Force Microscopy of Surface Interaction of Biological Species (DNA, proteins and drugs)

  • Fabrication and Characterization of Nanomaterials (Nanoarray, Nanotube, Nanoparticles) and Bio-functionalized Nanomaterials

  • Electrochemical and Optical Biosensor Development

Selected Publications

31. Shardai S. Johnson, Racquel O. Broomfield, Gerry Y. Woodland, Jonathan G. Breitzer, Daniel E. Autrey, Shubo Han, and Zhiping Luo. Electron Probe Microanalysis of Electrospun Nd2O3 Nanofibers Doped with Ce/Zn. Microsc. Microanal. 2017, 23 (Suppl 1), 201.

30. Zhu, M.; Patel, S. H.; Han, S. DJ-1, A Parkinson’s disease related protein, aggregates under denaturing conditions and co-aggregates with α-synuclein through hydrophobic interaction. Biochimica et Biophysica Acta (BBA) – General Subjects,  2017,  1861(7),  1759-1769.

29. Kharabsheh, H. A.; Han, S.;  Allen, S; Chao, S.L. Metabolism of chlorpyrifos by Pseudomonas aeruginosa increases toxicity in adult zebrafish (Danio rerio).  International Biodeterioration & Biodegradation, 2017, 121, 114-121.

28.   Han, S.;  Umera, K.;  Han, X.; Graham. J.M. Surface Electrochemical Oxidation and Polymerization Mechanism of Epicatechin, Electrochemica Acta, 2013, 90, 27-34.

27. Zhu,M;   Han,S.;  Fink, A.L.. Oxidized Quercetin Inhibits α-Synuclein Fibrillization, Biochimica et Biophysica Acta (BBA)-General Subjects. 2013, 1830, 2872-2881.

26.  Jiang,D.;  Rauda, I.;  Han, S.;  Chen, S.;  Zhou, F. Aggregation Pathways of the Amyloid β(1-42) Peptide Depend on Its Colloidal Stability and Ordered β-Sheet Stacking, Langmuir, 2012, 28, 12711-12721.

25.    Bhattacharya, P.;   Czejdo,B.; Han,S.;  Siddique, M. Behavior Based Approach for Robot Navigation and Chemical Anomaly Tracking. in S. Jeschke, H. Liu, and Schilberg (Eds.): ICIRA 2011, Part II, LNAI 7102, pp. 317-327, 2011. Springer-Verlag Berlin Heidelberg 2011.

24.    Hong, D.; Han, S.; Fink, A. L., N. Uversky, N. V. Characterization of the Non-Fibrillar α-Synuclein Oligomers(2011), Protein and Peptide Letters, 18( 3), pp. 230-240.

23. Qin, Z.; Hu, D.; Han, S.; Hong, D.; Fink, A.L. Role of different regions of α-synuclein in the assembly of fibrils. Biochemistry (2007), 46(46), 13322-133

22. Qin, Z.; Hu, D.; Han, S.; Reaney, S. H.; Di Monte, D. A.; Fink, A.L. Effect of 4-hydroxy-2-nonenal modification on α-synuclein aggregation. Journal of Biological Chemistry (2007), 282(8), 5862-5870.

21. Martinez, Z.; Zhu, M; Han, S.; Fink, A.L. GM1 specifically interacts with α-synuclein and inhibits fibrillation. Biochemistry (2007), 46(7), 1868-1877.

20. Wang, J.; Zhu X.; Han, S. Electrochemistry of bilayer lipid membranes. Recent Res. Devel. Biophys., 5(2006): 319-332.

19. Wang, Y., Han, S., Briseno, A.L., Sanedrin, R.J.G., and Zhou, F., A modified nanosphere lithography for the fabrication of aminosilane/polystyrene nanoring arrays and the subsequent attachment of gold or DNA-capped gold nanoparticles. Journal of Materials Chemistry, 2004, 14. 3488-3494.

18. Zhu, M., Han, S., Zhou, F., Carter, S.A., and Fink, A.L., Annular oligomeric Amyloid Intermediates Observed by in Situ Atomic Force Microscopy. Journal of Biological Chemistry, 2004. 279(23): 244529.

17. Zhu, M., Rajamani, S., Kaylor, J., Han, S., Zhou, F., and Fink, A.L., The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils. Journal of Biological Chemistry, 2004. 279(26): 26846-57.

16. Briseno, A.L., Han, S., Rauda, I.E., Zhou, F., Toh, C.-S., Nemanick, E.J., and Lewis, N.S., Electrochemical Polymerization of Aniline Monomers Infiltrated into Well-Ordered Truncated Eggshell Structures of Polyelectrolyte Multilayers. Langmuir, 2004. 20(1): 219 -226.

15. Han, S., Sun, X.Z., Wang, J., Li, X., Zhou, F.M., and Momand, J., AFM studies of interactions of proteins with surface-confined ds DNA. Biophysical Journal, 2003. 84(2): 471A-471A.

14. Han, S., Ralin, D., Wang, J., Li, X., and Zhou, F., Attachment of Monoclonal Antibody Molecules to Surface-Confined DNA Duplexes Imaged by Atomic Force Microscopy. Langmuir, 2003. 19(21): 8943-89509.

13. Chickneyan, Z.S., Briseno, A.L., Shi, X., Han, S., Huang, J., and Zhou, F., Polyelectrolyte-Mediated Assembly of Copper Phthalocyanine Tetrasulfonate Multilayers and the Subsequent Production of Nanoparticulate Copper Oxide Thin Films. Journal of Nanoscience and Nanotechnology, 2004. 4: 628-634.

12. Sun, X.Z., Vinci, C., Makmura, L., Han, S., Tran, D., Nguyen, J., Hamann, M., Grazziani, S., Sheppard, S., Gutova, M., Zhou, F., Thomas, J., and Momand, J., Formation of Disulfide Bond in p53 Correlates with Inhibition of DNA Binding and Tetramerization. Antioxidants & Redox Signaling, 2003. 5(5): 655-665.

11. Han, S., Briseno, A.L., Shi, X., Mah, D.A., and Zhou, F., Polyelectrolyte-coated nanosphere lithographic patterning of surfaces: Fabrication and characterization of electropolymerized thin polyaniline honeycomb films. Journal of Physical Chemistry B, 2002. 106(25): 6465-6472.

10. Han, S., Shi, X., and Zhou, F., Polyelectrolyte Hollow Sphere Lithographic Patterning of Surfaces: Construction of 2-Dimensional Well-Ordered Metal Arrays. Nano Letters, 2002. 2(2): 97-100.

9. Shi, X., Han, S., Sanedrin, R.J., Galvez, C., Ho, D.G., Hernandez, B., Zhou, F., and Selke, M., Formation of Cobalt Oxide Nanotubes: Effect of Intermolecular Hydrogen Bonding between Co(III) Complex Precursors Incorporated onto Colloidal Templates. Nano Letters, 2002. 2(4): 289-293.

8. Shi, X., Han, S., Sanedrin, R.J., Zhou, F., and Selke, M., Synthesis of Cobalt Oxide Nanotubes from Colloidal Particles Modified with a Co(III)-Cysteinato Precursor. Chemistry of Materials, 2002. 14(4): 1897-1902.

7. Huang, E., Satjapipat, M., Han, S., and Zhou, F., Surface Structure and Coverage of an Oligonucleotide Probe Tethered onto a Gold Substrate and Its Hybridization Efficiency for a Polynucleotide Target. Langmuir, 2001. 17(4): 1215-1224.

6. Han, S., Lin, J., Satjapipat, M., Baca, A.J., and Zhou, F., A three-dimensional heterogeneous DNA sensing surface formed by attaching oligodeoxynucleotide-capped gold nanoparticles onto a gold-coated quartz crystal. Chemical Communications (Cambridge, United Kingdom), 2001(7): 609-610.

5. Han, S., Lin, J., Zhou, F., and Vellanoweth, R.L., Oligonucleotide-Capped Gold Nanoparticles for Improved Atomic Force Microscopic Imaging and Enhanced Selectivity in Polynucleotide Detection. Biochemical and Biophysical Research Communications, 2000. 279: 265-269.

4. Han, S., Zhu, M., Yuan, Z., and Li, X., A methylene blue-mediated enzyme electrode for the determination of trace mercury(II), mercury(I), methylmercury, and mercury-glutathione complex. Biosensors & Bioelectronics, 2001. 16(1-2): 9-16.

3. Zhu, M., Han, S., and Yuan, Z., beta-cyclodextrin polymer as the immobilization matrix for peroxidase and mediator in the fabrication of a sensor for hydrogen peroxide. Journal of Electroanalytical Chemistry, 2000. 480(1-2): 255-261.

2. Han, S., Li, X., Guo, G., Sun, Y., and Yuan, Z., Voltammetric measurement of microorganism populations. Analytica Chimica Acta, 2000. 405(1-2): 115-121.

1. Yuan, Z., Zhu, M., and Han, S., Supramolecular inclusion complex formation and application of b-cyclodextrin with heteroanthracene ring cationic dyes. Analytica Chimica Acta, 1999. 389(1-3): 291-298.


    1. Rassman, W., Ralin, D., Zhou, F., and Han, S., Method and apparatus for recognizing molecular compounds, in U.S. Pat. Appl. Publ. 2003, (USA). Us. p. 17 pp.

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