Dr. Eid Haddad
Dr. Eid Haddad received his Ph.D. from The Pennsylvania State University (PSU) and worked as a Post-Doctoral Fellow at PSU, then as a Post-Doctoral Research Associate at The University of Arkansas, USA. Dr. Haddad is an Assistant Professor of Physiology at Fayetteville State University, a constituent institution of The University of North Carolina. Prior to that, Dr. Haddad worked at ImmunoBio Inc. (IBI) as Senior Research Scientist and later became the Vice President of Research and Development. While at IBI, he was a visiting scientist at the Department of Molecular Biomedical Sciences, North Carolina State University. He conducted research on the application of a novel vaccine technology toward the development of viral and bacterial vaccines for mammalian including human applications. Prior to that, he held research and managerial positions at Embrex Inc. with the last position being Senior Manager of Global Product Development. He worked on the development of veterinary viral vaccines against several economically important veterinary diseases. His research led to the company gaining regulatory approval for two viral vaccines here in the USA, and for one of them in multiple countries. Dr. Haddad and his colleagues published many articles in Vaccinology, Immunology, and Endocrinology in high-quality peer-reviewed scientific journals and presented his work at multiple national and international conferences.
Publications
Haddad, E. E. 2018. What can we learn from in ovo embryo vaccination? International Journal of Vaccines and Vaccination, 5(5): 23-24
Christine L. Fleischacker, Miriam Segura-Totten, SEA-PHAGES, Rebecca A. Garlena, Deborah Jacobs-Sera, Welkin H. Pope, Daniel A. Russell, and Graham F. Hatfull. 2017. Genome Sequence of Mycobacterium Phage CrystalP. GenBank: KY319168.1 https://www.ncbi.nlm.nih.gov/nuccore/KY319168
Haddad, E. E. 2016. A Message from the Immune System: A Vaccine Technology in Needs of Exploration! International Journal of Vaccines and Vaccination, 2(4): 00038. http://medcraveonline.com/IJVV/volume_issues?issueId=768&volumeId=248
Senter, P., Mattox, U., and Haddad, E. E. 2016. Snake to monster: Conrad Gessner's Schlangenbuch and the evolution of the dragon in the literature of natural history. J. Folklore Research 53:67-124. http://muse.jhu.edu/article/610975
Darrell R. Kapczynski, Alison Martin, Eid E. Haddad, Daniel J. King. 2012. Protection from Clinical Disease Against Three Highly Virulent Strains of Newcastle Disease Virus Following In Ovo Application of an Antibody-Antigen Complexed Vaccine in Maternally-Antibody Positive Chickens. Avian Dis. 56(3): 555-560. http://www.ncbi.nlm.nih.gov/pubmed/23050473
Jin Huk Choi, Joe Dekker, Stephen C. Schafer, Jobby John, Craig E. Whitfill, Christopher S. Petty, Eid E. Haddad, and Maria A. Croyle. 2012. Optimized Adenovirus-Antibody Complexes Stimulate Strong Cellular and Humoral Immune Responses Against an Encoded Antigen in Naïve Mice and Those with Pre-Existing Immunity. Clin. Vaccine Immunol. 2012, 19(1):84. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255947
Ricks, C. A., A. Avakian, T. Bryan, R. Gildersleeve, E. Haddad, R. Ilich, L. Murray, P. Phelps, R. Poston, C. Whitfill, and C. Williams. 1999. In ovo vaccination technology. Adv. in Vet. Med. (41); Veterinary Vaccines and Diagnostics., Ronald D. Schultz, Ed. Academic Press, New York. PP 495-515. http://www.ncbi.nlm.nih.gov/pubmed/9890038
Haddad, E. E., C. E. Whitfill, A. P. Avakian, C. A. Ricks, P. D. Andrews, J. A. Thoma, and P. S. Wakenell. 1997. Efficacy of a Novel Infectious Bursal Disease Virus Immune Complex Vaccine in Broiler Chickens. Avian Dis. 41:882-889. http://www.ncbi.nlm.nih.gov/pubmed/9454922
Jeurissen, S. H. M., E. M. Janse, P. R. Lehrbach, E. E. Haddad, A. P. Avakian, and C. E. Whitfill. 1998. The Working Mechanism of an Immune Complex Vaccine that Protects Chickens Against Infectious Bursal Disease. Immunology, 95:494-500. http://www.ncbi.nlm.nih.gov/pubmed/9824516
Johnston, P. A., H. Liu, T. O'Connell, P. Phelps, M. Bland, J. Tyczkowski, A. Kemper, T. Harding, A. Avakian, E. Haddad, C. Whitfill, R. Gidersleeve, and C. A. Ricks. 1996. Application of in ovo technology. Poultry Sci.76:165-178. http://www.ncbi.nlm.nih.gov/pubmed/9037703
Whitfill, C. E., E. E. Haddad, C. A. Ricks, J. K. Skeeles, L. A. Newberry, M. N. Beasley, P. D. Andrews, J. A. Thoma, and P. S. Wakenell. 1995. Determination of optimal formulation of a novel infectious bursal disease virus (IBDV) vaccine constructed by mixing bursal disease antibody with IBDV. Avian Dis. 39:687-699. http://www.ncbi.nlm.nih.gov/pubmed/8719201
Haddad, E. E., C. E. Whitfill, C. A. Ricks, T. Fredericksen, D. Rowe, L. Owen, A. Baldridge, L. Murray, and J. A. Thoma. 1994. Adaptation of the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay for the determination of virus-neutralizing antibodies using the virus-neutralization assay. Avian Dis. 38:755-761. http://www.ncbi.nlm.nih.gov/pubmed/7702508
Haddad, E. E., N. B. Anthony, R. Bridges, C. Whitfill, J. K. Skeeles, and J. Thoma. 1994. Evaluation of the Humoral Immune Response to Different Antigens in Arkansas Regressor and Progressor Chickens. Poultry Sci., 73:341-345. http://www.ncbi.nlm.nih.gov/pubmed/8146082
Haddad, E. E. and M. M. Mashaly. 1992. Augmentation of natural killer (cNK) cells activity by supernatant from in vitro mitogen-stimulated lymphocyte obtained from in vivo hormone-treated immature male chickens. Immunol. Invest. 21:365-375. http://www.ncbi.nlm.nih.gov/pubmed/1398785
Haddad, E. E. and M. M. Mashaly. 1991. In vivo effects of TRH, T3, and cGH on antibody production and T- and B- lymphocytes proliferation in immature male chickens. Immunol. Invest. 20:557-568 http://www.ncbi.nlm.nih.gov/pubmed/1757115
Haddad, E. E. and M. M. Mashaly. 1991. Chicken growth hormone, Triiodothyronine and thyrotropin releasing hormone modulation of the levels of chicken natural cell-mediated cytotoxicity. Dev. Comp. Immunol. 15:65-71. http://www.ncbi.nlm.nih.gov/pubmed/1904829
Haddad, E. E. and M. M. Mashaly. 1990. Effect of thyrotropin releasing hormone (TRH), Triiodothyronine (T3) and chicken Growth hormone (cGH) on growth of lymphoid organs and leukocyte populations in immature male chickens. Poultry Sci. 69:1094-1102. http://www.ncbi.nlm.nih.gov/pubmed/2122431
Haddad, E. E. and M. M. Mashaly. 1989. Effect of thyroidectomy of immature male chickens on circulating thyroid hormones and on the response to TSH and chronic cold exposure. Poultry Sci. 68:169-176. http://www.ncbi.nlm.nih.gov/pubmed/2704673
Refereed Abstract and Conference Proceedings:
Sherry, Barbara and Eid Haddad. 2008. The hunt for new vaccines: immune complex vaccine technology generates novel veterinary and human medicine application. Magazine of the College of Veterinary Medicine, North Carolina State University.
Haddad, Eid. 2007. Immune Complex Vaccine (ICV) Technology; a Novel Approach in Vaccine Development. 2nd Annual Targeted Immunotherapeutics and Vaccine Summit, Novel Vaccines: Bridging Research, Development, and Production. Cambridge, MA
Avakian, P. A., P. S. Wakenell, D. B. Link, C. Blackmore, E. E. Haddad, and C. E. Whitfill. 2004. Protection to Newcastle disease and infection bronchitis in broiler chickens vaccinated in-ovo for infectious bursal disease with an IBDV-antibody complex vaccine and vaccinated post hatch for ND and IB. Proceedings of the XXII World Poultry Congress, Istanbul, P 706.
Haddad, E. Eid., Alan* P. Avakian, Craig E. Whitfill, Don E. Grosse, Donald B. Link, Craig S. Blackmore, and Patricia S. Wakenell. 2004. Immunological evaluation of a novel Newcastle disease vaccine administered in ovo on day 18 of embryonic age to specific pathogen free and commercial broiler birds. Proceedings of the XXII World Poultry Congress, Istanbul, P 703.
Ramki* Nagaraj, Eid E. Haddad, Don E. Grosse, Donald B. Link, Rosemary D. Stowers, and Craig E. Whitfill. 2004. Virus Replication and Onset of Protection Following in ovo Vaccination with a Novel Newcastle Disease Vaccine in SPF Birds. Unpublished, Programs of the 141st AVMA meeting
Haddad*, E. Eid., Craig E. Whitfill, Don E. Grosse, Craig Blackmore, and Patricia S. Wakenell. 2004. Immune profile following in ovo vaccination with a novel Newcastle disease vaccine in commercial broilers. Unpublished, Programs of the 141st AVMA meeting.
Haddad*, E. Eid., Craig E. Whitfill, Alan P. Avakian, Don Grosse, and Michael Martin. 2004. Compatibility of a novel Newcastle disease vaccine with Marek's vaccine when co-administered in ovo. Program and Abstracts of the World Veterinary Poultry Association, and the 140th AVMA meeting. P 108.
Haddad*, E. Eid., Mike Martin, Jon Schaeffer, Karen Burnes, & Craig Whitfill. 2003. In ovo vaccination against Newcastle disease: Field safety evaluation. 52nd Western Poultry Disease Conference. Pp 34-36.
Haddad*, E. Eid., Craig E. Whitfill., Alan P. Avakian, Donald B. Link., Patricia S. Wakenell. 2002. Safety and Efficacy of a novel Newcastle disease vaccine administered in ovo to SPF and commercial broiler birds. 51st Western Poultry Disease Conference, XXVII Convention Annual ANECA. Pp 101-103.
Jeurissen, S.H.M., Janse, E.M., Lahrbach, P.R., Haddad, E.E., Avakian, A. & Whitfill, C.E. 2001. The effect of an IBDV immune complex vaccine on various cell populations after in ovo injection. In E.F. Kaleta & U. Heffels-Redmann (Eds.), Proceedings of the II International Symposium on Infectious Bursal Disease and chicken Infectious Anaemia (pp. 444 _453). Giessen, Germany: Rauischholzhausen.
Avakian*, P. Alan., Craig E. Whitfill., Eid E. Haddad., Jan-Kees van den Wijngaard., and Nick. J. Chettle. 2001. The characteristics of infectious bursal disease virus antibody complex vaccines and their application in broilers with maternal immunity. In, "Cost Action 839, Immunosuppressive viral disease in poultry, 3rd meeting of working group 3: Passive protection and vaccination (current and future possibilities) in the presence of maternally derived antibody" Pulawy, Poland. Pp 55 - 68.
Wijingaard*, Jan-Kees van Dan., Alan Avakian., Craig Whitfill., and Eid Haddad. In ovo IBD vaccinations surpass conventional approach. World Poultry - Special'01, Pp 16-17.
Whitfill, Craig., Avakian, Alan., Haddad*, Eid., and Wakenell, Patricia. Virus-antibody complex vaccines: Present and future. 2000. XVI Central American and the Caribbean Poultry Congress. Panama City, Republic of Panama.
Whitfill*, Craig., Avakian, Alan., Haddad, Eid., and Wakenell, Patricia. Virus-antibody complex vaccines: Present and future. 2000. Proceedings of the Association of Colombian Medical Veterinarian and Zoological Specialist (AMEVEA), Bogota, Colombia.
Eid E. Haddad*, Craig E. Whitfill, Alan P. Avakian, Fred D. Clark, Patricia D. Vanzant, Donald B. Link, and Patricia S. Wakenell. 1999. Safety and efficacy of a novel Newcastle disease (ND) vaccine when administered in ovo on day 18 of embryonic development to SPF and broiler embryos. Unpublished, Programs of the 136th AVMA meeting.
Baines, David, Wijingaard, Jan-Kees van Dan., Avakian, Alan., Haddad, Eid., and Whitfill, Craig. 1999. State of the art in ovo technology. International Hatchery practice, Vol. 13, No. 6, p15-17.
Haddad*, E. E., Whitfill, C. E., Avakian, A. P., Clark, F. D., Vanzant, P. D., Link, D. B., and Wakenell, P. S. 1999. In ovo vaccination with a novel Newcastle Disease (ND) vaccine in SPF and broiler embryos; evaluation of safety and efficacy. Proc. 48th West. Poult. Dis. Conf. PP. 117.
Haddad*, E. E., Whitfill, C. E., Avakian, A. P., Clark, F. D., Vanzant, P. D., Link, D. B., and Wakenell, P. S. 1999. Safety and efficacy of a novel Newcastle Disease (ND) vaccine when administered in ovo on day 18 of embryonic development to SPF and broiler embryos. Unpublished. Program of the 136th AVMA meeting.
Wijngaard*, JC., Heijmans, JF., Elbers, AR., Davelaar, FG., Lehrbach, PR., Baines, D., Avakian, AP., Whitfill, CE., and Haddad, EE. 1998. Bursamune in ovo safety and efficacy trials in European broiler chickens. Proceedings 10th European Poultry Conference. Volume I: 359-361.
Whitfill*, C. E., A. P. Avakian, E. E. Haddad, R. Ryan, J. C. Wijngaard, D. Baines, N. Chettle, and P. R. Lehrbach. 1997. Control of Infectious Bursal Disease in broilers by in ovo vaccination as demonstrated by laboratory and controlled field trials using a virus-antibody complex vaccine XIth International Congress of the World Veterinary Poultry Association, Budapest, Hungary, P. 10.
Whitfill*, C. E., A. P. Avakian, R. P. Gildersleeve, E. E. Haddad, C. A. Ricks, N. Chettle, and P. R. Lehrbach. 1996. Protection against very virulent infectious bursal disease (IBD) challenge in England by in ovo vaccination with a virus-antibody complex IBD vaccine. Proc. 45th West. Poult. Dis. Conf. PP. 189-190.
Whitfill*, C. E. A. P. Avakian, R. P. Gildersleeve, E. E. Haddad, C. A. Ricks, N. Chettle, and P. R. Lehrbach. 1996. In ovo technology for control of infectious bursal disease (IBD). Proceedings of the XX World's poultry Congress. P. 89.
Edens*, F. W., C. R. Parkhurst, G. B. Havenstein, E. Haddad, C. E. Whitfill. 1996. Use of chicken infectious bursa disease vaccine to decrease spiking mortality in turkeys. Poult. Sci. 75 (Suppl. 1) P. 115.
Whitfill*, C. E., E. E. Haddad, A. P. Avakian, R. P. Gildersleeve, and C. A. Ricks. 1996. How do we know our chicks are vaccinated? International Hatchery practice. PP 28-29.
Edens*, F. W., C. R. Parkhurst, C. E. Whitfill, E. E. Haddad, and A. P. Avakian. 1995. Performance of broiler chickens given either a complex of infectious bursal disease vaccine conjugated with IBDV neutralizing antibody (VNF) or a commercial IBDV vaccine. Poultry Sci. 74(Suppl. 1):24.
Wilson*, M. K., L. A. Newberry, J. K. Skeeles, G. R. Bayyari, W. E. Huff, J. N. Beasley, R. W. McNew, F. D. Clark, C. E. Whitfill, and E. Haddad. 1995. A study of proventriculitis, its association with infectious bursal disease virus, and the efficacy of commercial IBDV vaccines in prevention. The 46th North Central Avian Dis. Conf. Minneapolis/St. Paul, p 118.
Whitfill*, C. E., A. P. Avakian, E. E. Haddad, and C. A. Ricks. 1995. Virus-Antibody Complex Vaccines. The 46th North Central Avian Dis. Conf. pp 42-51.
Skeeles*, J. K., G. R. Bayyari, L. A. Newberry, M. A. Wilson, W. E. Huff, J. N. Beasley, F. D. Clark, C. E. Whitfill, and E. Haddad. 1995. The involvement of infectious bursal disease virus as a cause of proventriculitis in chickens. Paper presented to The 46th North central Avian Disease Conf., Minneapolis/St. Paul.
Haddad*, E. E., P. A. Andrews, L. A. Newberry, C. E. Whitfill, A. P. Avakian, C. A. Ricks, and J. K. Skeeles. 1995. Safety and efficacy of a novel avian tenosynovitis vaccine prepared by complexing the virus with reovirus antisera and administered in ovo to 18-day-old SPF embryos. Unpublished. Program of the 132nd AVMA meeting. p 117.
Avakian*, A. P., J. S. Guy, C. E. Whitfill, E. E. Haddad, and C. A. Ricks. 1995. Newcastle disease virus-antiserum complex vaccines administered in ovo and day of age to SPF and broiler chickens. Unpublished. Program of the 132nd AVMA meeting. p 117.
Avakian*, A. P. P. Wyeth, C. E. Whitfill, C. A. Ricks, E. E. Haddad, and N. Chettle. 1994. Development of immunity in broilers to IBDV following in ovo vaccination with a novel live IBDV vaccine (BDA-IBD-BLEN). Unpublished. Program of the 131st AVMA meeting. p 137.
Avakian*, A. P.., P. S. Wakenell, E. E. Haddad, C. E. Whitfill, C. A. Ricks, and J. Thoma. 1994. Effects of a novel IBDV vaccine (BDA-IBD-BLEN) on the response of broiler chickens to Newcastle disease virus vaccination and challenge. Proc. 43rd West. Poult. Dis. Conf. PP. 103-105.
Whitfill*, C. E., E. E. Haddad, P. Wyeth, C. A. Ricks, A. P. Avakian, and N. Chettle. 1994. Development of immunity to various antigens by chickens following in ovo vaccination with a novel live IBDV vaccine (BDA-IBD-BLEN). Unpublished. Program of the 131st AVMA meeting. p 137.
Whitfill*, C. E., C. Ricks, E. Haddad, and A. Avakian, 1993. In ovo administration of a novel infectious bursal disease vaccine in broiler chickens. Proceedings of the Xth International Congress of the World Veterinary Poultry Association, P. 154.
Whitfill*, C. E., C. Ricks, A. Avakian, P. Wakenell, E. Haddad, P. Andrews, J. K. Skeeles, and J. Thoma. 1993. Efficacy of a novel infectious bursal disease vaccine, BDA-IBD-BLEN, and HVT Marek's vaccine, when combined and injected into day-old seronegative chickens. Poultry Sci. 72(Suppl. 1):198.
Avakian*, A. P., C. E. Whitfill, E. E. Haddad, C. A. Ricks, K. Skeeles, P. Andrews, and J. Thoma. 1993. Efficacy of a novel infectious bursal disease (IBD) vaccine administered in ovo to broiler chickens. Poultry Sci. 72(Suppl. 1):49.
Haddad*, E. E., C. E. Whitfill, C. A. Ricks, A. P. Avakian, K. Skeeles, P. Andrews, and J. Thoma. 1993. Efficacy of a novel infectious bursal disease (IBD) vaccine administered in ovo to SPF chickens. Poultry Sci. 72(Suppl. 1):49.
Whitfill* C. E., C. A. Ricks, A. P. Avakian, E. E. Haddad, P. D. Andrews, J. K. Skeeles, and J. A. Thoma. 1993. Protective dose levels of novel BDA-BLEN infectious bursal disease vaccine in SPF and broiler birds. Proc. 42nd West. Poult. Dis. Conf. p. 58.
Whitfill* C. E., C. A. Ricks, A. P. Avakian, P. Wakenell, E. Haddad, P. Andrews, and J. K. Skeeles. 1993. Efficacy of a new infectious bursal disease vaccine, BDA-IBD-BLEN, and HVT Marek's vaccine, when combined and injected in day old seronegative chickens. Poult. Sci. 72 (Suppl. 1):198.
Whitfill* C. E., C. A. Ricks, E. E. Haddad, P. D. Andrews, and J. K. Skeeles, 1992. An infectious bursal disease (IBD) vaccine for day 18 in ovo administration in chickens. Proceedings of the XIX World's Congress, Vol. P. 11.
Whitfill* C. E., C. Ricks, E. Haddad, P. Andrews, J. K. Skeeles, and J. Thoma, 1992. Infectious bursal disease (IBD) vaccine for day of age administration in broiler chickens. Poult. Sci. 71 (Suppl. 1):59.
Whitfill*, C. E., C. A. Ricks, E. E. Haddad, P. D. Andrews, J. K. Skeeles, and J. A. Thoma. 1992. Infectious bursal disease (IBD) vaccine for day one of age administration in broiler chickens. Poult. Sci. 71 (Suppl. 1):59.
Haddad*, E., J. Skeeles, J. Beasley, P. Andrews, N. Anthony, C. Whitfill, R. Bridges, and J. Thoma. 1992. Effects of in ovo Cyclophosphamide (CY) treatment on the regression of Rous Sarcoma Virus (RSV)-induced tumor in Arkansas regressor (R) and progressor (Pr) chicken lines. Poult. Sci. 71 (Suppl. 1):11.
Whitfill*, C. E., C. A. Ricks, E. E. Haddad, P. D. Andrews, J. K. Skeeles, and J. A. Thoma. 1992. An infectious bursal disease vaccine for day 18 in ovo administration in chickens. Ann. World's Poult. Cong. Meeting, Amsterdam, the Netherlands, 1992.
Whitfill*, C. E., C. A. Ricks, E. E. Haddad, P. D. Andrews, and J. K. Skeeles. 1992. A novel infectious bursal disease (IBD) vaccine for day 18 in ovo administration. Poult. Sci. 71 (Suppl. 1):183.
Whitfill*, C. E., C. A. Ricks, D. G. Rowe, E. L. Owen, E. E. Haddad, P. D. Andrews, J. K. Skeeles, and J. A. Thoma. 1992. An infectious bursal disease (IBD) vaccine for day 18 in ovo administration in chickens. Proc. 41st West. Poult. Dis. Conf. P. 72.
Whitfill*, C. E., C. A. Ricks, T. L. Fredericksen, J. K. Tyczkowskia, D. Rowe, L. Owen, J. Hutchins, E. Haddad, P. Andrews, J. K. Skeeles, J. Beasley, L. Newberry, J. A. Thoma, P. Wakenell, N. Ismail, and J. Hardisty. 1991. A novel infectious bursal disease (IBD) vaccine for day old chickens effective in presence or absence of maternal antibodies. Proc. 40th West. Poult. Dis. Conf. P. 286-287.
Whitfill*, C., C. Ricks, T. Fredericksen, E. Haddad, P. Andrews, J. Skeeles, J. Beasley, and J. Thoma. 1991. A novel infectious bursal disease (IBD) vaccine for day old chickens effective in the presence or absence of maternal antibodies. Poult. Sci. 70 (Suppl. 1):130.
Haddad*, E. E. and M. M. Mashaly. 1988. Effect of TRH, T3, and cGH on the cytotoxic activity of Natural Killer (NK) cells as well as the proliferative ability of T- and B-lymphocytes in immature male chickens. Poult. Sci. 67 (Suppl. 1):93.
Haddad*, E. E. and M. M. Mashaly. 1988. Effect of TRH, T3, and chicken growth hormone (cGH) on lymphoid organs, leukocyte population and antibody production in immature male chickens. Poult. Sci. 67 (Suppl. 1):92.
Haddad*, E. E. and M. M. Mashaly. 1987. Thyroid hormone profile after thyroidectomy in immature male chickens. Unpublished. Annual Graduate Research Exhibition, the Pennsylvania State University, University Park, PA.
Haddad*, E. E., M. M. Mashaly, J. M. Bachman, and R. F. Wideman. 1986. Is there an extrathyriodal tissue in immature male chickens? Poult. Sci. 65 (Suppl. 1):52.
Thoma JA, Haddad, Eid E., Whitfill, Craig E., Avakian, Alan P (2002). Method of treatment. United States Patent #6,440,408. http://www.freepatentsonline.com/6440408.html
Thoma JA, Haddad, Eid E., Whitfill, Craig E., Avakian, Alan P (2005). Methods of treatment. United States patent #6,890,527 http://www.freepatentsonline.com/6890527.html