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Dr. Shubo Han

Shubo Han

PhD of Chemistry

Research Interests
Research Interests
  • AFM and spectroscopic research on protein interactions in neurodegenerative diseases
  • Nanostructured electrochemical and spectrometric biosensors
  • LCMS and ICP research on natural products and envrironmental samples

47. Girja Mani Aryal, Krishna Prasad Kandel, Ram Kumar Bhattarai, Basant Giri, Menuka Adhikari, Alisha Ware, Shubo Han, Gibin George, Zhiping Luo, Bhoj Raj Gautam, Bhanu Bhakta Neupan. Material Properties of Traditional Handmade Paper Samples Fabricated from Cellulosic Fiber of Lokta BushesGM Aryal, ACS omega 7 (36), 32717-32726

46. S Jones, A Ware, T Wright, D Keith, S Han, D Autrey, B Gautam.Ti3C2TX MXene Hole Transport Layer for Polymer Non-Fullerene Solar Cells. Microscopy and Microanalysis 28 (S1), 926-927, 2022.

45. M Adhikari, TL Moore, ZT Morris, S Han, Z Luo. Characterization of Electrospun ZnCr2O4 Spinel Nanofibers. Microscopy and Microanalysis 28 (S1), 2656-2657, 2022.

44. M Adhikari, ZT Morris, T Watson, G George, S Han, Z Luo. Observation of Electrospun Yttrium Cobalt Oxide YCoO3 Nanofibers Calcined at Different Temperatures. Microscopy and Microanalysis 28 (S1), 2662-2663, 2022.

43. Pelucarte, KD; Hatchell, TA; George, G; Ede, SR;  Adhikari, M; Lin, Y; Wen, J; Luo, Z; and Han, S. Electrospun porous La-Sr-Co-Ni-O nanofibers for highly sensitive non-enzymatic glucose detection. Materials Advances 3, 2096-2103, 2022.

42. SR Ede, C Poasada, J Guffie, W Ratcliff, H Wu, S Han, Z Luo. Synthesis and Characterization of Sr2Co2-xFexO5+δ Perovskite Oxides. Microscopy and Microanalysis 27 (S1), 714-715, 2021.

41. T Wright, W Ware, J Barkley, S Han, B Gautam. Morphology of Perylene Dimide based Polymer Non-Fullerene Solar Cells: Effect of Thermal Annealing. Microscopy and Microanalysis 27 (S1), 2430-2431, 2021

40. GM Aryal, W Ware, S Han, G George, Z Luo, KP Kandel, B Gautam. Microscopic Characterization of Eco-friendly Lokta Paper. Microscopy and Microanalysis 27 (S1), 720-721, 2021.

39. J Barkley, L Reyes-Rosa, S Han, A Siamaki, B Gautam. Aggregation Effect in Polymer Graphene Composites for Optical Sensing Applications. ECS Meeting Abstracts, 1662, 2021.

38. S Jones, A Ware, T Wright, D Keith, E Danilov, S Han, D Autrey, B Gautam. Charge Transfer in Conjugated Polymer Mxene Interface. ECS Meeting Abstracts, 1051, 2021.

37. Ede, S.R.; Collins, C.N.; Posada, C.D.; George, G.; Wu, H.; Ratcliff, W.D.; Lin, Y.; Wen, J.; Han, S.; Luo, Z. Intermediate Sr2Co1.5Fe0.5O6−δ Tetragonal Structure between Perovskite and Brownmillerite as a Model Catalyst with Layered Oxygen Deficiency for Enhanced Electrochemical Water Oxidation. ACS Catalysis 11 (7), 4327-4337, 2021. http//DOI:10.1021/acscatal.1c00465

36. Allen-Perry, K.; Straka, W.; Keith, D.; Han, S.; Reynolds, L.; Gautam, B.; Autrey, D.E. Tuning the Magnetic Properties of Two-Dimensional MXenes by Chemical Etching. Materials, 14, 694, 2021.

35. Ware, W.; Wright, T.; Mao, Y.; Han, S.; Guffie, J.; Danilov, E.O.; Rech, J.; You, W.; Luo, Z.; Gautam, B. Aggregation Controlled Charge Generation in Fullerene Based Bulk Heterojunction Polymer Solar Cells: Effect of Additive. Polymers, 13, 115, 2021.

34. Hatchell, Tashi; Hutchenson, Kasci; George, Gibin; Luo, Zhiping; Han; Shubo. Morphological and Compositional Characterization of Electrochemically Active Perovskite Oxides for Sensing Biological Molecules. Microscopy and Microanalysis , 1039,2020. DOI: 10.1017/ S1431927620022369.

33. Ware,Washat; Devita, Antony; Wright, Tia; Han, Shubo; Gautam, Bhoj. Morphological Characterization of Polymer Blends: Impact of Side Chain Modification. Microscopy and Microanalysis, 932, 2020. DOI: 10.1017/S1431927620021388.

32. Jessa Guffie, Carlos Posada, Gibin George, Shubo Han and Zhiping Luo. Electrospun Rare-Earth Orthovanadate Scintillator Nanofibers Analyzed by EPMA. Microsc. Microanal. 25 (Suppl 2), 2366, 2019.

31. Shardai S. Johnson, Racquel O. Broomfield, Gerry Y. Woodland, Jonathan G. Breitzer, Daniel E. Autrey, Shubo Han, and Zhiping Luo. Electron Probe Microanalysis of Electrospun Nd2O3 Nanofibers Doped with Ce/Zn. Microsc. Microanal. 23 (Suppl 1), 201, 2017.

30. Zhu, M.; Patel, S. H.; Han, S. DJ-1, A Parkinson’s disease related protein, aggregates under denaturing conditions and co-aggregates with α-synuclein through hydrophobic interaction. Biochimica et Biophysica Acta (BBA) – General Subjects, 1861(7), 1759-1769, 2017.

29. Kharabsheh, H. A.; Han, S.; Allen, S; Chao, S.L. Metabolism of chlorpyrifos by Pseudomonas aeruginosa increases toxicity in adult zebrafish (Danio rerio), , International Biodeterioration & Biodegradation, 121, 114–121, 2017.

28. Han, S.; Umera, K.; Han, X.; Graham. J.M. Surface Electrochemical Oxidation and Polymerization Mechanism of Epicatechin, Electrochemica Acta, 90, 27-34, 2013.

27. Zhu,M; Han,S.; Fink, A.L.. Oxidized Quercetin Inhibits α-Synuclein Fibrillization, Biochimica et Biophysica Acta (BBA)-General Subjects. 1830, 2872-2881, 2013.

26. Jiang,D.; Rauda, I.; Han, S.; Chen, S.; Zhou, F. Aggregation Pathways of the Amyloid β(1-42) Peptide Depend on Its Colloidal Stability and Ordered β-Sheet Stacking, Langmuir, 28, 12711-12721, 2012.

25. Bhattacharya, P.; Czejdo,B.; Han,S.; Siddique, M. Behavior Based Approach for Robot Navigation and Chemical Anomaly Tracking. in S. Jeschke, H. Liu, and Schilberg (Eds.): ICIRA 2011, Part II, LNAI 7102, pp. 317-327, 2011. Springer-Verlag Berlin Heidelberg 2011.

24. Hong, D.; Han, S.; Fink, A. L., N. Uversky, N. V. Characterization of the Non-Fibrillar α-Synuclein Oligomers, Protein and Peptide Letters, 18( 3), pp. 230-240, 2011.

23. Qin, Z.; Hu, D.; Han, S.; Hong, D.; Fink, A.L. Role of different regions of α-synuclein in the assembly of fibrils. Biochemistry, 46(46), 13322-133, 2007.

22. Qin, Z.; Hu, D.; Han, S.; Reaney, S. H.; Di Monte, D. A.; Fink, A.L. Effect of 4-hydroxy-2-nonenal modification on α-synuclein aggregation. Journal of Biological Chemistry, 282(8), 5862-5870, 2007.

21. Martinez, Z.; Zhu, M; Han, S.; Fink, A.L. GM1 specifically interacts with a-synuclein and inhibits fibrillation. Biochemistry, 46(7), 1868-1877, 2007.

20. Wang, J.; Zhu X.; Han, S. Electrochemistry of bilayer lipid membranes. Recent Res. Devel. Biophys., 5: 319-332, 2006.

19. Wang, Y., Han, S., Briseno, A.L., Sanedrin, R.J.G., and Zhou, F., A modified nanosphere lithography for the fabrication of aminosilane/polystyrene nanoring arrays and the subsequent attachment of gold or DNA-capped gold nanoparticles. Journal of Materials Chemistry, 14. 3488-3494, 2004.

18. Zhu, M., Han, S., Zhou, F., Carter, S.A., and Fink, A.L., Annular oligomeric Amyloid Intermediates Observed by in Situ Atomic Force Microscopy. Journal of Biological Chemistry, 279(23): 244529, 2004.

17. Zhu, M., Rajamani, S., Kaylor, J., Han, S., Zhou, F., and Fink, A.L., The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils. Journal of Biological Chemistry, 279(26): 26846-57, 2004.

16. Briseno, A.L., Han, S., Rauda, I.E., Zhou, F., Toh, C.-S., Nemanick, E.J., and Lewis, N.S., Electrochemical Polymerization of Aniline Monomers Infiltrated into Well-Ordered Truncated Eggshell Structures of Polyelectrolyte Multilayers. Langmuir, 20(1): 219 -226, 2004.

15. Han, S., Sun, X.Z., Wang, J., Li, X., Zhou, F.M., and Momand, J., AFM studies of interactions of proteins with surface-confined ds DNA. Biophysical Journal, 84(2): 471A-471A, 2003.

14. Han, S., Ralin, D., Wang, J., Li, X., and Zhou, F., Attachment of Monoclonal Antibody Molecules to Surface-Confined DNA Duplexes Imaged by Atomic Force Microscopy. Langmuir, 19(21): 8943-89509, 2003.

13. Chickneyan, Z.S., Briseno, A.L., Shi, X., Han, S., Huang, J., and Zhou, F., Polyelectrolyte-Mediated Assembly of Copper Phthalocyanine Tetrasulfonate Multilayers and the Subsequent Production of Nanoparticulate Copper Oxide Thin Films. Journal of Nanoscience and Nanotechnology, 4: 628-634, 2004.

12. Sun, X.Z., Vinci, C., Makmura, L., Han, S., Tran, D., Nguyen, J., Hamann, M., Grazziani, S., Sheppard, S., Gutova, M., Zhou, F., Thomas, J., and Momand, J., Formation of Disulfide Bond in p53 Correlates with Inhibition of DNA Binding and Tetramerization. Antioxidants & Redox Signaling, 5(5): 655-665, 2003.

11. Han, S., Briseno, A.L., Shi, X., Mah, D.A., and Zhou, F., Polyelectrolyte-coated nanosphere lithographic patterning of surfaces: Fabrication and characterization of electropolymerized thin polyaniline honeycomb films. Journal of Physical Chemistry B, 106(25): 6465-6472, 2002.

10. Han, S., Shi, X., and Zhou, F., Polyelectrolyte Hollow Sphere Lithographic Patterning of Surfaces: Construction of 2-Dimensional Well-Ordered Metal Arrays. Nano Letters, 2(2): 97-100, 2002.

9. Shi, X., Han, S., Sanedrin, R.J., Galvez, C., Ho, D.G., Hernandez, B., Zhou, F., and Selke, M., Formation of Cobalt Oxide Nanotubes: Effect of Intermolecular Hydrogen Bonding between Co(III) Complex Precursors Incorporated onto Colloidal Templates. Nano Letters, 2(4): 289-293, 2002.

8. Shi, X., Han, S., Sanedrin, R.J., Zhou, F., and Selke, M., Synthesis of Cobalt Oxide Nanotubes from Colloidal Particles Modified with a Co(III)-Cysteinato Precursor. Chemistry of Materials, 14(4): 1897-1902, 2002.

7. Huang, E., Satjapipat, M., Han, S., and Zhou, F., Surface Structure and Coverage of an Oligonucleotide Probe Tethered onto a Gold Substrate and Its Hybridization Efficiency for a Polynucleotide Target. Langmuir, 17(4): 1215-1224, 2001.

6. Han, S., Lin, J., Satjapipat, M., Baca, A.J., and Zhou, F., A three-dimensional heterogeneous DNA sensing surface formed by attaching oligodeoxynucleotide-capped gold nanoparticles onto a gold-coated quartz crystal. Chemical Communications (Cambridge, United Kingdom), (7): 609-610, 2001.

5. Han, S., Lin, J., Zhou, F., and Vellanoweth, R.L., Oligonucleotide-Capped Gold Nanoparticles for Improved Atomic Force Microscopic Imaging and Enhanced Selectivity in Polynucleotide Detection. Biochemical and Biophysical Research Communications, 279: 265-269, 2000.

4. Han, S., Zhu, M., Yuan, Z., and Li, X., A methylene blue-mediated enzyme electrode for the determination of trace mercury(II), mercury(I), methylmercury, and mercury-glutathione complex. Biosensors & Bioelectronics, 16(1-2): 9-16, 2001.

3. Zhu, M., Han, S., and Yuan, Z., beta-cyclodextrin polymer as the immobilization matrix for peroxidase and mediator in the fabrication of a sensor for hydrogen peroxide. Journal of Electroanalytical Chemistry, 480(1-2): 255-261, 2000.

2. Han, S., Li, X., Guo, G., Sun, Y., and Yuan, Z., Voltammetric measurement of microorganism populations. Analytica Chimica Acta, 405(1-2): 115-121, 2000.

1. Yuan, Z., Zhu, M., and Han, S., Supramolecular inclusion complex formation and application of b-cyclodextrin with heteroanthracene ring cationic dyes. Analytica Chimica Acta, 389(1-3): 291-298, 1999.


Rassman, W., Ralin, D., Zhou, F., and Han, S., Method and apparatus for recognizing molecular compounds, in U.S. Pat. Appl. Publ. 2003, (USA). Us. p. 17 pp.

Current and Former Research Students
Current and Former Research Students
  • Bryson D Core'2023, NSF EIR Scholar
  • Antonio S. Garcia'2023, NSF EIR Scholar
  • Angelina K. Locke'2023, NSF LSAMP Scholar
  • Jennifer McCartin'2021,  Integrated DNA Technologies (IDT)
  • Kasci D. Pelucarte (Class 2021,Osteopathic Medicine at Campbell University), NSF EIR Scholar
  • Tashi A. Hatchell (Class 2021, US Air Force Officer), NSF PREM Scholar
  • Larissa Stewart (Left, Class of 2017, Medical Program of Howard University) Shivaliben H Patel'2016, now working at  Catalent
  • Emily Oshita G'2016, now working as a STEM program coordinator  at Fayetteville State University.
  • Bridget Venegas (2nd Left), Burrell College of Osteopathic Medicine 
  • Niyogushima Juliely (2nd Right), PhD Student at University of Nebraska - Lincoln
  • Kaodi Umerah,  M.D. Specializes in Internal Medicine, Indiana University
  • Lior Vered,  PhD at University of North Carolina at Chapel Hill
  • James Thomas, Doctor of Pharmacy at Campbell University
  • Andrew Lee,  Doctor  of Osteopathic Medicine at Campbell University